Illinois’ labor force is shrinking at the rate of .24% per annum. Opioid-involved drug overdoses are contributing to this poor state of labor force, on average drug overdoses account for 17.2 deaths per 100,000 Illinoisans. This paper is an attempt to quantify the impact of opioid use on labor productivity. Results of a differential equation modeling of the opioid epidemic suggests that for every 1% increase in opioid prescriptions, the state will lose 4% of its labor productivity.